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Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 139-143 doi: 10.1007/s11684-019-0736-2

Abstract: The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults wasClinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from NovemberA total of 163 (98.3%) patients with viral pneumonia were treated with antibiotics.A total of 39 of the 163 (23.9%) patients did not meet the guidelines for drug selection for viral CAPThe unreasonable use of antibacterial drugs for the treatment of viral CAP in adults is a serious concern

Keywords： adult     antibiotic     viral pneumonia    

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Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

Yutao Liu, Yaxia Di, Shuai Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 239-246 doi: 10.1007/s11684-017-0509-8

Abstract: We aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNC

Keywords： ventilator-associated pneumonia (VAP)     pneumonia     risk factors     surgery for head and neck cancer (SHNC)    

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theIn this review, the current understanding of innate immunity contributing to the restriction of RNA viralBesides the main role of immune cells in combating viral infection, the intercellular transfer of pathogenThis knowledge provides an enhanced understanding of the innate immune response to RNA viral infectionsin general and aids in the preparation for the existing and next emerging viral infections.

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronic hepatitis B. A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median of 28 months. Compared with the patients without cirrhosis, the patients progressed to cirrhosis were older and with higher HBV-DNA levels at end point. However, there was no significant difference in cirrhosis progression between different HBV-DNA groups at baseline ( = 0.531). Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis ( = 0.019). The results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis B e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosis. The relative risk ratios were 1.898, 1.918, 8.976, and 1.006, respectively. Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up.

Keywords： hepatitis B     chronic     viral load     liver cirrhosis    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: and corticosteroid resistance has been reported in patients with Mycoplasma pneumoniae (MP) pneumonia

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein    

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microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale    

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Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy

Maliwan NACONSIE,Peng ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 285-294 doi: 10.15302/J-FASE-2016119

Abstract: Also, two viral diseases, cassava mosaic disease (CMD) and cassava brown streak disease (CBSD), causeGenetic engineering provides promising approaches to improve nutritional value and increase resistance to viralprotein content by overexpression of nutritious storage proteins and improving cassava resistance to viral

Keywords： Manihot esculenta     protein enhancement     RNA interference     transgenesis     virus resistance    

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Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 449-461 doi: 10.1007/s11684-017-0589-5

Abstract: In this review, we summarize and discuss the latest progress in the development of small-molecule viralThese viruses can interfere with the specific steps of viral life cycle by blocking the binding betweenvirus and host cells, disrupting viral endocytosis, disturbing membrane fusion, and interrupting viralWe also discuss some general strategies for developing small-molecule viral inhibitors.

Keywords： emerging and re-emerging viruses     small-molecule inhibitor     coronavirus     Ebola virus     Zika virus     life cycle    

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Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Article

Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak

Engineering 2023, Volume 26, Issue 7,   Pages 54-62 doi: 10.1016/j.eng.2022.08.007

Abstract:

The essential role of immunoglobulin G (IgG) in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the Fc domain that occur under such circumstances. These glycans impact the antibody stability, half-life, secretion, immunogenicity, and effector functions. Therefore, in this study, we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits (sialylation, galactosylation, fucosylation, and bisecting N-acetylglucosamine (GlcNAc))—of 64 patients with influenza, 77 patients with coronavirus disease 2019 (COVID-19), and 56 healthy controls. Our study revealed a significant decrease in IgG galactosylation, sialylation, and bisecting GlcNAc (where the latter shows the most significant decrease) in deceased COVID-19 patients, whereas IgG fucosylation was increased. On the other hand, IgG galactosylation remained stable in influenza patients and COVID-19 survivors. IgG glycosylation in influenza patients was more time-dependent: In the first seven days of the disease, sialylation increased and fucosylation and bisecting GlcNAc decreased; in the next 21 days, sialylation decreased and fucosylation increased (while bisecting GlcNAc remained stable). The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses, while the observed changes in deceased COVID-19 patients may indicate its deviation.

Keywords： Influenza     COVID-19     Viral infection     Glycosylation     Immunoglobulin G     Pneumonia    

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Mouth the mirror of lungs: where does the connection lie?

Jananni Muthu,Sivaramakrishnan Muthanandam,Jaideep Mahendra

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 405-409 doi: 10.1007/s11684-016-0476-5

Abstract:

Periodontitis is the chronic destructive disease of the periodontium (Gums) caused by host bacterial interactions. The effect of such host bacterial interactions in oral cavity also evokes a systemic response. Numerous studies have found common mechanisms of destruction for periodontal diseases and other chronic diseases like diabetes mellitus, atherosclerosis, respiratory diseases, and adverse pregnancy outcomes. Oral colonization by respiratory pathogens appears to be a risk factor for development of respiratory diseases and oral interventions aimed at reducing oral bacterial count have resulted in reduced incidence of these reparatory illness. This reflects the importance of oral hygiene among patients with respiratory illness. This review highlights the association between periodontal diseases and respiratory diseases.

Keywords： periodontitis     respiratory diseases     acute pneumonia     COPD    

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A brief review of microRNA and its role in PRRSV infection and replication

Xuekun GUO,Wenhai FENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 114-120 doi: 10.15302/J-FASE-2014022

Abstract: shown to be capable of modulating PRRSV infection and replication by multiple ways such as targeting viralgenomic RNA, targeting viral receptor and inducing antiviral response.

Keywords： porcine reproductive and respiratory syndrome virus (PRRSV)     microRNA     antiviral     viral tropism    

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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 497-508 doi: 10.1007/s11684-017-0572-1

Abstract:

Viral infections cause at least 10%–15% of all human carcinomas.Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamentalMeanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic

Keywords： genome-editing tools     tumorigenic virus     delivery method     off-target effect     virus-related carcinoma    

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Importance of Viral Disease in Dairy Cow Fertility Review

D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng

Engineering 2020, Volume 6, Issue 1,   Pages 26-33 doi: 10.1016/j.eng.2019.07.020

Abstract:

Many viral diseases are endemic in cattle populations worldwide.There is also significant evidence that viral infections have additional actions in dairy cows, whichAcute infection with non-cytopathic bovine viral diarrhea virus (BVDV) in mid-gestation increases abortion

Keywords： Bovine viral diarrhea virus     Bovine herpesvirus-1     Bovine herpesvirus-4     Schmallenberg virus     Bluetongue    

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The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 333-344 doi: 10.1007/s11684-013-0275-1

Abstract: The disease progressed to severe pneumonia, sustained hypoxia, and coagulation abnormalities.

Keywords： avian influenza A (H7N9) virus     epidemiology     contacts     person-to-person transmission    

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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections

Frontiers of Medicine doi: 10.1007/s11684-023-1011-0

Abstract: Paxlovid therapy tended toward early viral clearance and low viral load on Day 8.

Keywords： Paxlovid     hemodialysis     SARS-CoV-2     viral load     chest CT scan    

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Title Author Date Type Operation

Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Journal Article

Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

Yutao Liu, Yaxia Di, Shuai Fu

Journal Article

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia

Journal Article

Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy

Maliwan NACONSIE,Peng ZHANG

Journal Article

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Journal Article

Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients

Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak

Journal Article

Mouth the mirror of lungs: where does the connection lie?

Jananni Muthu,Sivaramakrishnan Muthanandam,Jaideep Mahendra

Journal Article

A brief review of microRNA and its role in PRRSV infection and replication

Xuekun GUO,Wenhai FENG

Journal Article

Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Journal Article

Importance of Viral Disease in Dairy Cow Fertility

D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng

Journal Article

The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Journal Article

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections

Journal Article